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Issue 28, 2009
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Phosphate-assisted peptide ligation

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Abstract

A novel ligation method for the synthesis of phosphopeptides and peptides is described, which utilises the inherent reactivity of a peptide bearing an N-terminal phosphoserine or phosphothreonine residue to facilitate amide bond formation with a range of C-terminal peptide thioesters.

Graphical abstract: Phosphate-assisted peptide ligation

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Article information


Submitted
01 Apr 2009
Accepted
28 Apr 2009
First published
26 May 2009

Chem. Commun., 2009, 4260-4262
Article type
Communication

Phosphate-assisted peptide ligation

G. L. Thomas and R. J. Payne, Chem. Commun., 2009, 4260
DOI: 10.1039/B906492C

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