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Issue 28, 2009
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Phosphate-assisted peptide ligation

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A novel ligation method for the synthesis of phosphopeptides and peptides is described, which utilises the inherent reactivity of a peptide bearing an N-terminal phosphoserine or phosphothreonine residue to facilitate amide bond formation with a range of C-terminal peptide thioesters.

Graphical abstract: Phosphate-assisted peptide ligation

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The article was received on 01 Apr 2009, accepted on 28 Apr 2009 and first published on 26 May 2009

Article type: Communication
DOI: 10.1039/B906492C
Chem. Commun., 2009, 4260-4262

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    Phosphate-assisted peptide ligation

    G. L. Thomas and R. J. Payne, Chem. Commun., 2009, 4260
    DOI: 10.1039/B906492C

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