Issue 23, 2009
From the journal:

Chemical Communications

Recognition of anti-mycolic acid antibody at self-assembled mycolic acid antigens on a gold electrode: a potential impedimetric immunosensing platform for active tuberculosis†

Nsovo S. Mathebula,a   Jeseelan Pillay,a   Gianna Toschi,a   Jan A. Verschoorb  and  Kenneth I. Ozoemena*ac  

* Corresponding authors

a Department of Chemistry, University of Pretoria, South Africa

b Department of Biochemistry, University of Pretoria, South Africa

c Energy & Processes Unit, Materials Science & Manufacturing, Council for Scientific and Industrial Research (CSIR), Pretoria, Pretoria 0001, South Africa
E-mail: kozoemena@csir.co.za
Fax: +27-12-8412135
Tel: +27-12-8413664

Abstract

Electrochemical impedimetric recognition by anti-mycolic acid antibodies, present in tuberculosis (TB)-positive human serum co-infected with human immunodeficiency virus (HIV), of mycolic acids (MA) integrated into a self-assembled monolayer of N-(2-mercaptoethyl)octadecanamide on a gold electrode is described, proving that the MA-based electrode can satisfactorily discriminate between a TB-positive and a TB-negative serum, thus offering promise as a potential impedimetric immunosensing platform for active tuberculosis.

Graphical abstract: Recognition of anti-mycolic acid antibody at self-assembled mycolic acid antigens on a gold electrode: a potential impedimetric immunosensing platform for active tuberculosis

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Article information

DOI
https://doi.org/10.1039/B905192A
Article type
Communication
Submitted
13 Mar 2009
Accepted
28 Apr 2009
First published
15 May 2009

Chem. Commun., 2009, 3345-3347

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Recognition of anti-mycolic acid antibody at self-assembled mycolic acid antigens on a gold electrode: a potential impedimetric immunosensing platform for active tuberculosis

N. S. Mathebula, J. Pillay, G. Toschi, J. A. Verschoor and K. I. Ozoemena, Chem. Commun., 2009, 3345 DOI: 10.1039/B905192A

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