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Issue 25, 2009
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Recent advances in the understanding of the interaction of antidepressantdrugs with serotonin and norepinephrine transporters

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Abstract

The biogenic monoamine transporters are integral membrane proteins that perform active transport of extracellular dopamine, serotonin and norepinephrine into cells. These transporters are targets for therapeutic agents such as antidepressants, as well as addictive substances such as cocaine and amphetamine. Seminal advances in the understanding of the structure and function of this transporter family have recently been accomplished by structural studies of a bacterial transporter, as well as medicinal chemistry and pharmacological studies of mammalian transporters. This feature article focuses on antidepressant drugs that act on the serotonin and/or the norepinephrine transporters. Specifically, we focus on structure–activity relationships of these drugs with emphasis on relationships between their molecular properties and the current knowledge of transporter structure.

Graphical abstract: Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters

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Article information


Submitted
12 Feb 2009
Accepted
25 Mar 2009
First published
07 May 2009

Chem. Commun., 2009, 3677-3692
Article type
Feature Article

Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters

J. Andersen, A. S. Kristensen, B. Bang-Andersen and K. Strømgaard, Chem. Commun., 2009, 3677 DOI: 10.1039/B903035M

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