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Issue 15, 2009
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Doubly dearomatising intramolecular coupling of a nucleophilic and an electrophilicheterocycle

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Abstract

Isonicotinamides carrying N-furanylmethyl, N-pyrrolylalkyl or N-thiophenylmethyl substituents at nitrogen undergo cyclisation induced by an electrophile, giving spirocyclic compounds or doubly spirocyclic compounds in which both the nucleophilic and electrophilicheterocycles are dearomatised.

Graphical abstract: Doubly dearomatising intramolecular coupling of a nucleophilic and an electrophilicheterocycle

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Article information


Submitted
23 Jan 2009
Accepted
18 Feb 2009
First published
12 Mar 2009

Chem. Commun., 2009, 1964-1966
Article type
Communication

Doubly dearomatising intramolecular coupling of a nucleophilic and an electrophilicheterocycle

H. Brice and J. Clayden, Chem. Commun., 2009, 1964
DOI: 10.1039/B901558B

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