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Issue 31, 2009
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Advances in gene delivery through molecular design of cationic lipids

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Abstract

This feature article describes the recent developments in the design of cationic lipids and their applications in gene delivery. Various structure–activity investigations explaining the variations in gene transfection efficacies with respect to different molecular structures of the cationic lipids have been discussed. Gene transfer abilities are presented in relation to aggregation properties of different aqueous formulations such as cationic liposomes and surfactant aggregates from various amphiphiles and cationic lipids, as a function of their hydrophobic parts, linkers and head groups.

Graphical abstract: Advances in gene delivery through molecular design of cationic lipids

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Publication details

The article was received on 12 Jan 2009, accepted on 13 May 2009 and first published on 03 Jul 2009


Article type: Feature Article
DOI: 10.1039/B900666B
Chem. Commun., 2009, 4632-4656

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    Advances in gene delivery through molecular design of cationic lipids

    S. Bhattacharya and A. Bajaj, Chem. Commun., 2009, 4632
    DOI: 10.1039/B900666B

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