Advances in gene delivery through molecular design of cationic lipids
This feature article describes the recent developments in the design of cationic lipids and their applications in gene delivery. Various structure–activity investigations explaining the variations in gene transfection efficacies with respect to different molecular structures of the cationic lipids have been discussed. Gene transfer abilities are presented in relation to aggregation properties of different aqueous formulations such as cationic liposomes and surfactant aggregates from various amphiphiles and cationic lipids, as a function of their hydrophobic parts, linkers and head groups.
- This article is part of the themed collection: 20th Anniversary of the CRSI: Celebrating Indian Chemistry in ChemComm