Issue 37, 2009
From the journal:

Chemical Communications

Synthesis of a monophosphoryl lipid A derivative and its conjugation to a modified form of a tumor-associated carbohydrateantigen GM3†

Qianli Wang,a   Jie Xuea  and  Zhongwu Guo*a  

* Corresponding authors

a Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, USA
E-mail: zwguo@chem.wayne.edu
Fax: +1 313-577-8822
Tel: +1 313-577-2557

Abstract

An efficient synthesis of a derivative of monophosphoryl lipid A suitable for coupling to various structures for the construction of glycoconjugate vaccines and its conjugation with an N-modified form of the tumor-associated antigen GM3 is presented.

Graphical abstract: Synthesis of a monophosphoryl lipid A derivative and its conjugation to a modified form of a tumor-associated carbohydrate antigen GM3

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Article information

DOI
https://doi.org/10.1039/B907351E
Article type
Communication
Submitted
14 Apr 2009
Accepted
10 Aug 2009
First published
27 Aug 2009

Chem. Commun., 2009, 5536-5537

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Synthesis of a monophosphoryl lipid A derivative and its conjugation to a modified form of a tumor-associated carbohydrate antigen GM3

Q. Wang, J. Xue and Z. Guo, Chem. Commun., 2009, 5536 DOI: 10.1039/B907351E

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