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Issue 28, 2009
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Synthetic studies on vincorine: access to the 3a,8a-dialkyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole skeleton

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Abstract

Synthetic studies on vincorine are described; the conversion of 3-aminoethyl-3-alkyloxindoles to 3a,8a-dialkyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indoles has been achieved through an addition–cyclization sequence, and a fully functionalized key intermediate was constructed with this method.

Graphical abstract: Synthetic studies on vincorine: access to the 3a,8a-dialkyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole skeleton

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Supplementary files

Article information


Submitted
08 Apr 2009
Accepted
12 May 2009
First published
09 Jun 2009

Chem. Commun., 2009, 4275-4277
Article type
Communication

Synthetic studies on vincorine: access to the 3a,8a-dialkyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole skeleton

Y. Yasui, T. Kinugawa and Y. Takemoto, Chem. Commun., 2009, 4275 DOI: 10.1039/B907210A

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