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Issue 1, 2009
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Nitroxyl radicals as low toxic spin-labels for non-invasive magnetic resonance imaging of blood–brain barrier permeability for conventional therapeutics

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Abstract

The present study describes a novel non-radioactive methodology for in vivo non-invasive, real-time imaging of blood–brain barrier (BBB) permeability for conventional drugs, using nitroxyl radicals as spin-labels and magnetic resonance imaging (MRI).

Graphical abstract: Nitroxyl radicals as low toxic spin-labels for non-invasive magnetic resonance imaging of blood–brain barrier permeability for conventional therapeutics

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Article information


Submitted
26 Sep 2008
Accepted
20 Oct 2008
First published
13 Nov 2008

Chem. Commun., 2009, 53-55
Article type
Communication

Nitroxyl radicals as low toxic spin-labels for non-invasive magnetic resonance imaging of blood–brain barrier permeability for conventional therapeutics

Z. Zhelev, R. Bakalova, I. Aoki, K. Matsumoto, V. Gadjeva, K. Anzai and I. Kanno, Chem. Commun., 2009, 53
DOI: 10.1039/B816878D

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