Jump to main content
Jump to site search

Issue 4, 2009
Previous Article Next Article

Unprecedented carbon–carbon bond cleavage in nucleophilic aziridine ring opening reaction, efficient ring transformation of aziridines to imidazolidin-4-ones

Author affiliations

Abstract

N-Styryl-3-aryl-1-methylaziridine-2-carboxamides, which were readily obtained from the cross coupling reaction between 3-aryl-1-methylaziridine-2-carboxamides and 1-aryl-2-bromoethenes catalyzed by CuI/N,N-dimethylglycine in the presence of Cs2CO3, underwent a base-mediated intramolecular nucleophilic aziridine ring opening reaction effectively via the carbon–carbon bond cleavage of aziridine to afford the ring expanded imidazolidin-4-one products in good yields.

Graphical abstract: Unprecedented carbon–carbon bond cleavage in nucleophilic aziridine ring opening reaction, efficient ring transformation of aziridines to imidazolidin-4-ones

Back to tab navigation

Supplementary files

Publication details

The article was received on 12 Sep 2008, accepted on 20 Oct 2008 and first published on 18 Nov 2008


Article type: Communication
DOI: 10.1039/B816007D
Chem. Commun., 2009, 422-424

  •   Request permissions

    Unprecedented carbon–carbon bond cleavage in nucleophilic aziridine ring opening reaction, efficient ring transformation of aziridines to imidazolidin-4-ones

    J. Wang, Y. Hu, D. Wang, J. Pan, Z. Huang and M. Wang, Chem. Commun., 2009, 422
    DOI: 10.1039/B816007D

Search articles by author

Spotlight

Advertisements