Issue 19, 2008
From the journal:

Organic & Biomolecular Chemistry

Organocatalytic asymmetric ring-opening of aziridines†

Márcio W. Paixão,a   Martin Nielsen,a   Christian Borch Jacobsena  and  Karl Anker Jørgensen*a  

* Corresponding authors

a Danish National Research Foundation: Center for Catalysis, Department of Chemistry, Aarhus University, Aarhus C, Denmark
E-mail: kaj@chem.au.dk
Fax: +45 8619 6199
Tel: +45 8942 3910

Abstract

The organocatalytic ring-opening of N-tosyl protected aziridines by β-ketoesters under chiral PTC-conditions, leading to the formation of optically active aminoethyl functionalised compounds with up to 99% ee, has been developed.

Graphical abstract: Organocatalytic asymmetric ring-opening of aziridines

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Article information

DOI
https://doi.org/10.1039/B812369A
Article type
Communication
Submitted
18 Jul 2008
Accepted
06 Aug 2008
First published
20 Aug 2008

Org. Biomol. Chem., 2008,6, 3467-3470

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Organocatalytic asymmetric ring-opening of aziridines

M. W. Paixão, M. Nielsen, C. B. Jacobsen and K. A. Jørgensen, Org. Biomol. Chem., 2008, 6, 3467 DOI: 10.1039/B812369A

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