Issue 21, 2008
From the journal:

Organic & Biomolecular Chemistry

An efficient synthesis of chiral phosphinyl oxide pyrrolidines and their application to asymmetric direct aldol reactions†

Xue-Wei Liu,*a   Thanh Nguyen Le,a   Yunpeng Lu,a   Yongjun Xiao,a   Jimei Maa  and  Xingwei Lia  

* Corresponding authors

a Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
E-mail: xuewei@ntu.edu.sg
Fax: +65 6316 6984
Tel: +65 6316 8901

Abstract

Chiral pyrrolidine-based phosphinyl oxides were synthesized and their performance as organocatalysts for asymmetric direct aldol reactions was evaluated. High enantioselectivities and diastereoselectivies were achieved for a range of cyclic ketones and aromatic aldehydes.

Graphical abstract: An efficient synthesis of chiral phosphinyl oxide pyrrolidines and their application to asymmetric direct aldol reactions

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Article information

DOI
https://doi.org/10.1039/B811581H
Article type
Paper
Submitted
07 Jul 2008
Accepted
23 Jul 2008
First published
04 Sep 2008

Org. Biomol. Chem., 2008,6, 3997-4003

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An efficient synthesis of chiral phosphinyl oxide pyrrolidines and their application to asymmetric direct aldol reactions

X. Liu, T. N. Le, Y. Lu, Y. Xiao, J. Ma and X. Li, Org. Biomol. Chem., 2008, 6, 3997 DOI: 10.1039/B811581H

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