Issue 17, 2008
From the journal:

Organic & Biomolecular Chemistry

Chiral peptide nucleic acid monomers (PNAM) with modified backbones†

Alan Roy Katritzky*a  and  Tamari Narindoshvilia  

* Corresponding authors

a Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, USA
E-mail: katritzky@chem.ufl.edu
Fax: +1-352-392-9199
Tel: +1-352-392-0554

Abstract

Convenient high yielding syntheses of optically pure PNAMs comprising L- or D-serine, L-lysine and L-arginine units linked to thymine or Cbz-cytosine are described. Simple workup and inexpensive reagents are employed and free amino acids are used as coupling components.

Graphical abstract: Chiral peptide nucleic acid monomers (PNAM) with modified backbones

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Article information

DOI
https://doi.org/10.1039/B806141F
Article type
Paper
Submitted
11 Apr 2008
Accepted
04 Jun 2008
First published
09 Jul 2008

Org. Biomol. Chem., 2008,6, 3171-3176

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Chiral peptide nucleic acid monomers (PNAM) with modified backbones

A. R. Katritzky and T. Narindoshvili, Org. Biomol. Chem., 2008, 6, 3171 DOI: 10.1039/B806141F

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