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Issue 9, 2008
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A modular flow reactor for performing Curtius rearrangements as a continuous flow process

Marcus Baumann,a  Ian R. Baxendale,a  Steven V. Ley,*a  Nikzad Nikbin,a  Christopher D. Smitha  and  Jason P. Tierneyb 
Author affiliations

* Corresponding authors

a Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: svl1000@cam.ac.uk
Fax: +44 1223 336442
Tel: +44 1223 336398

b Neurology Lead Discovery Chemistry, Neurology CEDD, GlaxoSmithKline R and D, New Frontiers Science Park (North), Third Avenue, Harlow, UK

Abstract

The use of a mesofluidic flow reactor is described for performing Curtius rearrangement reactions of carboxylic acids in the presence of diphenylphosphoryl azide and trapping of the intermediate isocyanates with various nucleophiles.

Graphical abstract: A modular flow reactor for performing Curtius rearrangements as a continuous flow process

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Publication details

The article was received on 29 Jan 2008, accepted on 15 Feb 2008 and first published on 12 Mar 2008


Article type: Paper
DOI: 10.1039/B801631N
Citation: Org. Biomol. Chem., 2008,6, 1577-1586

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    A modular flow reactor for performing Curtius rearrangements as a continuous flow process

    M. Baumann, I. R. Baxendale, S. V. Ley, N. Nikbin, C. D. Smith and J. P. Tierney, Org. Biomol. Chem., 2008, 6, 1577
    DOI: 10.1039/B801631N

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