Issue 7, 2008
From the journal:

Organic & Biomolecular Chemistry

Bifunctional ligands based on the DOTA-monoamide cage

Alessandro Barge,a   Lorenzo Tei,b   Dharita Upadhyaya,a   Franco Fedeli,c   Lorena Beltrami,c   Rachele Stefanìa,c   Silvio Aime*c  and  Giancarlo Cravotto*a  

* Corresponding authors

a Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino, Via Giuria, Torino, Italy
E-mail: giancarlo.cravotto@unito.it
Fax: +39 0116707687
Tel: +39 0116707684

b Dipartimento di Scienze dell′Ambiente e della Vita, Università del Piemonte Orientale, via Bellini 25, G-Alessandria, Italy

c Dipartimento di Chimica IFM, Università di Torino, Via Giuria, Torino, Italy
E-mail: silvio.aime@unito.it
Fax: +39 0116707855
Tel: +39 0116706451

Abstract

Efficient routes to DOTA-monoamide ligands bearing amino, hydroxyl, aldehyde and maleimido groups are described. These functional groups, which can be spaced at will from the coordination cage, will readily react with suitable groups of targeting moieties. Bioconjugates obtained in this way can be used for diagnostic imaging and therapeutic applications.

Graphical abstract: Bifunctional ligands based on the DOTA-monoamide cage

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Article information

DOI
https://doi.org/10.1039/B715844K
Article type
Paper
Submitted
15 Oct 2007
Accepted
28 Jan 2008
First published
22 Feb 2008

Org. Biomol. Chem., 2008,6, 1176-1184

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Bifunctional ligands based on the DOTA-monoamide cage

A. Barge, L. Tei, D. Upadhyaya, F. Fedeli, L. Beltrami, R. Stefanìa, S. Aime and G. Cravotto, Org. Biomol. Chem., 2008, 6, 1176 DOI: 10.1039/B715844K

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