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Issue 7, 2008
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Bifunctional ligands based on the DOTA-monoamide cage

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Abstract

Efficient routes to DOTA-monoamide ligands bearing amino, hydroxyl, aldehyde and maleimido groups are described. These functional groups, which can be spaced at will from the coordination cage, will readily react with suitable groups of targeting moieties. Bioconjugates obtained in this way can be used for diagnostic imaging and therapeutic applications.

Graphical abstract: Bifunctional ligands based on the DOTA-monoamide cage

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Article information


Submitted
15 Oct 2007
Accepted
28 Jan 2008
First published
22 Feb 2008

Org. Biomol. Chem., 2008,6, 1176-1184
Article type
Paper

Bifunctional ligands based on the DOTA-monoamide cage

A. Barge, L. Tei, D. Upadhyaya, F. Fedeli, L. Beltrami, R. Stefanìa, S. Aime and G. Cravotto, Org. Biomol. Chem., 2008, 6, 1176
DOI: 10.1039/B715844K

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