Issue 1, 2008
From the journal:

Organic & Biomolecular Chemistry

Efficient C2 functionalisation of 2H-2-imidazolines

Robin S. Bon,a   Nanda E. Sprenkels,a   Manoe M. Koningstein,a   Rob F. Schmitz,a   Frans J. J. de Kanter,a   Alexander Dömling,b   Marinus B. Groena  and  Romano V. A. Orru*a  

* Corresponding authors

a Department of Chemistry, Vrije Universiteit Amsterdam, De Boelelaan 1083, Amsterdam, HV, The Netherlands
E-mail: orru@few.vu.nl
Fax: +31 20 5987488
Tel: +31 20 5987447

b Pharmaceutical Sciences & Chemistry, University of Pittsburgh, Pittsburgh, PA, USA

Abstract

Alkylation and oxidation of 2H-2-imidazolines, followed by regioselective deprotection, thionation and microwave-assisted Liebeskind–Srogl reaction, efficiently led to 2-aryl-2-imidazolines as new analogues of p53-hdm2 interaction inhibitors (Nutlins).

Graphical abstract: Efficient C2 functionalisation of 2H-2-imidazolines

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Article information

DOI
https://doi.org/10.1039/B713065A
Article type
Paper
Submitted
24 Aug 2007
Accepted
22 Oct 2007
First published
08 Nov 2007

Org. Biomol. Chem., 2008,6, 130-137

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Efficient C2 functionalisation of 2H-2-imidazolines

R. S. Bon, N. E. Sprenkels, M. M. Koningstein, R. F. Schmitz, F. J. J. de Kanter, A. Dömling, M. B. Groen and R. V. A. Orru, Org. Biomol. Chem., 2008, 6, 130 DOI: 10.1039/B713065A

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