Issue 4, 2008
From the journal:

Natural Product Reports

Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways

Elizabeth S. Sattely,a   Michael A. Fischbachb  and  Christopher T. Walsh*a  

* Corresponding authors

a Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Ave., Boston, MA, USA

b Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA, USA

Abstract

Covering: 1990 to February 2008

This review surveys efforts to reconstitute key steps in polyketide and nonribosomal peptide biosynthetic pathways with purified enzymes and substrates; 344 references are cited.

Graphical abstract: Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways

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Article information

DOI
https://doi.org/10.1039/B801747F
Article type
Review Article
Submitted
28 Feb 2008
First published
23 May 2008

Nat. Prod. Rep., 2008,25, 757-793

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Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways

E. S. Sattely, M. A. Fischbach and C. T. Walsh, Nat. Prod. Rep., 2008, 25, 757 DOI: 10.1039/B801747F

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