Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 22nd May 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 2, 2008
Previous Article Next Article

Convergent strategies for the total synthesis of polycyclic ether marine metabolites

Author affiliations

Abstract

Covering: up to 2007

Marine polycyclic ether natural products continue to fascinate chemists and biologists due to their exceptionally large and complex molecular architectures and potent and diverse biological activities. Tremendous progress has been made over the past decade toward the total synthesis of marine polycyclic ether natural products. In this area, a convergent strategy for assembling small fragments into an entire molecule always plays a key role in successful total synthesis. This review describes our efforts to develop convergent strategies for the synthesis of polycyclic ethers and their application to the total synthesis of gambierol, gymnocin-A, and brevenal, and to the partial synthesis of the central part of ciguatoxins and the nonacyclic polyether skeleton of gambieric acids.

Graphical abstract: Convergent strategies for the total synthesis of polycyclic ether marine metabolites

  • This article is part of the themed collection: Synthesis
Back to tab navigation

Publication details

The article was received on 01 Nov 2007 and first published on 17 Jan 2008


Article type: Review Article
DOI: 10.1039/B705664H
Nat. Prod. Rep., 2008,25, 401-426

  •   Request permissions

    Convergent strategies for the total synthesis of polycyclic ether marine metabolites

    M. Sasaki and H. Fuwa, Nat. Prod. Rep., 2008, 25, 401
    DOI: 10.1039/B705664H

Search articles by author

Spotlight

Advertisements