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Issue 7, 2008
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3-Chloromethylpyridyl bipyridinefac-tricarbonyl rhenium: a thiol-reactive luminophore for fluorescence microscopy accumulates in mitochondria

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Abstract

The 3-chloromethylpyridyl bipyridine fac tricarbonyl rhenium cation is a thiol-reactive luminescent agent with a long luminescence lifetime and large Stokes shift that is demonstrated by co-localisation studies to accumulate in mitochondria. This represents the first application of a 3MLCT luminescent agent for the specific targeting of a biological entity in imaging.

Graphical abstract: 3-Chloromethylpyridyl bipyridine fac-tricarbonyl rhenium: a thiol-reactive luminophore for fluorescence microscopy accumulates in mitochondria

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Article information


Submitted
08 Feb 2008
Accepted
18 Apr 2008
First published
23 May 2008

New J. Chem., 2008,32, 1097-1102
Article type
Letter

3-Chloromethylpyridyl bipyridine fac-tricarbonyl rhenium: a thiol-reactive luminophore for fluorescence microscopy accumulates in mitochondria

A. J. Amoroso, R. J. Arthur, M. P. Coogan, J. B. Court, V. Fernández-Moreira, A. J. Hayes, D. Lloyd, C. Millet and S. J. A. Pope, New J. Chem., 2008, 32, 1097
DOI: 10.1039/B802215A

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