Issue 5, 2008
From the journal:

New Journal of Chemistry

Toxicity and biodistribution of para-sulfonato-calix[4]arene in mice†‡

Anthony W. Coleman,*a   Said Jebors,a   Sebastien Cecillon,a   Pascale Perret,b   Dominique Garin,b   Danièle Marti-Battleb  and  Marcelle Moulinb  

* Corresponding authors

a IBCP CNRS Univ Lyon 1, UMR 5086, 7 passage du Vercors, Lyon, France
E-mail: aw.coleman@ibcp.fr
Fax: +33 4 7272 2690
Tel: +33 4 7272 2640

b Unité INSERM U877 (Radiopharmaceutiques Biocliniques), CHU Michallon, Hôpital de Grenoble, La Tronche, France
E-mail: Marcelle.Moulin@sim.hcuge.ch

Abstract

The acute in vivo toxicity of para-35S-sulfonato-calix[4]arene has been determined, with no toxicity for doses up to 100 mg kg−1. Biodistribution shows that the molecule is rapidly cleared in urine, that it does not accumulate in the liver and spleen, and is not observed in the brain.

Graphical abstract: Toxicity and biodistribution of para-sulfonato-calix[4]arene in mice

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Article information

DOI
https://doi.org/10.1039/B718962A
Article type
Letter
Submitted
10 Dec 2007
Accepted
14 Feb 2008
First published
22 Feb 2008

New J. Chem., 2008,32, 780-782

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Toxicity and biodistribution of para-sulfonato-calix[4]arene in mice

A. W. Coleman, S. Jebors, S. Cecillon, P. Perret, D. Garin, D. Marti-Battle and M. Moulin, New J. Chem., 2008, 32, 780 DOI: 10.1039/B718962A

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