Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.

Issue 36, 2008
Previous Article Next Article

The role of nanocomposites in bone regeneration

Author affiliations


Tissue engineering utilizes the expertise within the fields of materials science, biology, chemistry, transplantation medicine, and engineering to design materials that can temporarily serve in a structural and/or functional capacity while a defect is regenerated. Of prominence in the realm of regenerative medicine is the issue of bone disease and degeneration, particularly among an increasingly aging population. Traditional methods for bone and joint replacement enjoy increasing success, but restoration of native tissue architecture remains the ideal. Toward this goal, the design of a tissue equivalent that can integrate with native bone must take into account the characteristics of this unique tissue. Firstly, the extracellular matrix of bone is a hierarchical, heterogeneous material that has features with sizes that range from the nanoscale to the macroscale. Secondly, there is synergy between these features that gives rise to a composite material with defined nano-, micro-, and macrophases. Understanding the role of these phases should lead to improved materials to aid bone regeneration. Emulating the structure of bone is difficult; nevertheless, researchers are developing nanocomposite materials that take us one step closer to attaining the mechanical and biological properties of bone. This article discusses the role of nanoscale parameters and interactions in bone and presents a few examples of how engineered nanocomposites attempt to mimic the hierarchical structure of bone in order to achieve tissue regeneration rather than repair.

Graphical abstract: The role of nanocomposites in bone regeneration

Back to tab navigation

Publication details

The article was received on 19 Mar 2008, accepted on 16 May 2008 and first published on 25 Jul 2008

Article type: Application
DOI: 10.1039/B804692A
Citation: J. Mater. Chem., 2008,18, 4233-4241

  •   Request permissions

    The role of nanocomposites in bone regeneration

    M. R. Rogel, H. Qiu and G. A. Ameer, J. Mater. Chem., 2008, 18, 4233
    DOI: 10.1039/B804692A

Search articles by author