Issue 3, 2008
From the journal:

Green Chemistry

One-pot chemoenzymatic syntheses of enantiomerically-enriched O-acetyl cyanohydrins from aldehydes in ionic liquid†

Zhi-Liang Shen,a   Wei-Juan Zhou,a   Ya-Ting Liu,a   Shun-Jun Ji*b  and  Teck-Peng Loh*a  

* Corresponding authors

a Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
E-mail: teckpeng@ntu.edu.sg
Fax: (+65) 6791 1961
Tel: (+65) 6316 8899

b Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Renai Road, Suzhou Industrial Park, Suzhou, China

Abstract

A practical and efficient method for the synthesis of optically active O-acetyl cyanohydrins via one-pot lipase-catalyzed kinetic resolution of the in situ generated racemic cyanohydrins or O-acetyl cyanohydrins using an ionic liquid as both reaction media and promoter has been described.

Graphical abstract: One-pot chemoenzymatic syntheses of enantiomerically-enriched O-acetyl cyanohydrins from aldehydes in ionic liquid

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Article information

DOI
https://doi.org/10.1039/B717235D
Article type
Communication
Submitted
07 Nov 2007
Accepted
11 Jan 2008
First published
28 Jan 2008

Green Chem., 2008,10, 283-286

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One-pot chemoenzymatic syntheses of enantiomerically-enriched O-acetyl cyanohydrins from aldehydes in ionic liquid

Z. Shen, W. Zhou, Y. Liu, S. Ji and T. Loh, Green Chem., 2008, 10, 283 DOI: 10.1039/B717235D

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