Issue 22, 2008
From the journal:

Dalton Transactions

A technetium intermediate specifically promotes deprotection of trifluoroacetyl HYNIC during radiolabelling under mild conditions†

M. Bashir-Uddin Surfraz,a   Stefano C. G. Biagini*b  and  Philip J. Blower*c  

* Corresponding authors

a Cancer Research Group, Department of Biosciences, University of Kent, Canterbury, Kent

b Functional Materials Group, School of Physical Sciences, University of Kent, Canterbury, Kent
E-mail: s.biagini@kent.ac.uk
Fax: 01227 827724
Tel: 01227 8227724

c Division of Imaging Sciences, King's College London, The Rayne Institute, 4th Floor Lambeth Wing, St Thomas' Hospital, London
E-mail: philip.blower@kcl.ac.uk
Fax: 02 071 885442
Tel: 02 071 889513

Abstract

The trifluoroacetyl group protects the nucleophilic HYNIC from unwanted side reactions yet allows radiolabelling with technetium-99m under mild conditions, due to efficient and specific promotion of deprotection by a technetium complex intermediate.

Graphical abstract: A technetium intermediate specifically promotes deprotection of trifluoroacetyl HYNIC during radiolabelling under mild conditions

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Article information

DOI
https://doi.org/10.1039/B805110K
Article type
Communication
Submitted
26 Mar 2008
Accepted
03 Apr 2008
First published
14 Apr 2008

Dalton Trans., 2008, 2920-2922

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A technetium intermediate specifically promotes deprotection of trifluoroacetyl HYNIC during radiolabelling under mild conditions

M. B. Surfraz, S. C. G. Biagini and P. J. Blower, Dalton Trans., 2008, 2920 DOI: 10.1039/B805110K

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