The large-bite bis(phosphite) ligand [{(–OC10H6(µ-S)C10H6O–)P{µ-(–OC10H6(µ-S)C10H6O–)}P(–OC10H6(µ-S)C10H6O–)}] (P⁁P) (2) was obtained by the reaction of PCl3 and thiobis(2,2′-naphthol) (1). The stoichiometric reactions of 2 with elemental sulfur and selenium afforded the corresponding chalcogenide derivatives [(E)P⁁P(E)] (3, E = S; 4, E = Se) in good yield. Treatment of two equivalents of [ClAu(SMe2)] with 2 afforded a dinuclear complex [ClAu(P⁁P)AuCl] (5), whereas the 1 : 1 reaction with CuI yielded the [(P⁁P)CuI] (6) complex. The copper(I) complex 6 on treatment with various pyridyl derivatives, produced mixed-ligand complexes [(P⁁P)CuI(NC5H5)] (7), [(P⁁P)Cu(2,2′-bpy)]I (8), [(P⁁P)Cu(1,10-phen)]I (9) and {[(P⁁P)Cu(4,4′-bpy)]I}∞ (10). The compounds 2–5 were tested for their cytotoxic activity on the human cervical cancer (HeLa) cell line. Compounds 2 and 3 were found to inhibit proliferation of HeLa cells significantly. These agents also induced apoptotic cell death in cancer cells. Evidence presented in this study indicated that the compounds 2 and 3 activate the tumor suppressor protein p53 in the colon adenocarcinoma (HCT-116) cell line.
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