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Issue 12, 2008
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Protecting groups for RNA synthesis: an increasing need for selective preparative methods

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Abstract

RNA can be chemically synthesized by automated DNA/RNA synthesizers, using protected ribonucleosides activated as phosphoramidites. The efficiency of the synthesis depends greatly on the protecting groups used, especially the protecting group on the 2′-hydroxyl functionality. The strategies employed to place the protecting groups on the desired functionality are quite inefficient, requiring additional modifications of the substrate, or leading to mixtures of protected compounds. In this tutorial review, the methods available for the selective protection of ribonucleosides are commented on, introducing the reader to the synthetic challenges involved.

Graphical abstract: Protecting groups for RNA synthesis: an increasing need for selective preparative methods

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Publication details

The article was received on 27 Jul 2008 and first published on 03 Oct 2008


Article type: Tutorial Review
DOI: 10.1039/B809851D
Citation: Chem. Soc. Rev., 2008,37, 2668-2675
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    Protecting groups for RNA synthesis: an increasing need for selective preparative methods

    Á. Somoza, Chem. Soc. Rev., 2008, 37, 2668
    DOI: 10.1039/B809851D

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