Isolation, structure and fatty acid synthesis inhibitory activities of platensimycin B1–B3 from Streptomyces platensis

Chaowei Zhang; John Ondeyka; Deborah L. Zink; Bruce Burgess; Jun Wang; Sheo B. Singh

doi:10.1039/B810113B

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Isolation, structure and fatty acid synthesis inhibitory activities of platensimycin B₁–B₃ from Streptomyces platensis†

Chaowei Zhang,^a John Ondeyka,^a Deborah L. Zink,^a Bruce Burgess,^a Jun Wang^a and Sheo B. Singh*^a

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* Corresponding authors

^a Merck Research Laboratories, Rahway, New Jersey, USA
E-mail: sheo_singh@merck.com
Fax: 1(732) 594-6880
Tel: 1(732) 594-3222

Abstract

Platensimycin B₁–B₃ are natural congeners of platensimycin with modest to significant changes in the benzoic acid portion of the molecule, leading to attenuation in the biological activities and thus confirming the significance of the free carboxylate for the potent activity.

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Supplementary files

Physical data, copies of ¹H and ¹³C NMR, IR and UV spectra of all compounds, and FigureS1 PDF (988K)

Article information

DOI: https://doi.org/10.1039/B810113B
Article type: Communication
Submitted: 16 Jun 2008
Accepted: 15 Jul 2008
First published: 05 Sep 2008

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Chem. Commun., 2008, 5034-5036

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Isolation, structure and fatty acid synthesis inhibitory activities of platensimycin B₁–B₃ from Streptomyces platensis

C. Zhang, J. Ondeyka, D. L. Zink, B. Burgess, J. Wang and S. B. Singh, Chem. Commun., 2008, 5034 DOI: 10.1039/B810113B

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