Issue 41, 2008

99m-Technetium carbohydrate conjugates as potential agents in molecular imaging

Abstract

This feature article covers recent reports of work towards the development of 99mTc–carbohydrate based agents for use in SPECT imaging, particularly of cancerous tissue. An outline of some of the key biological functions and coordination chemistry of carbohydrates is given, along with an introduction to bioconjugation and molecular imaging. Technetium coordination chemistry and the subset of this involving bioconjugates are discussed before moving into the focus of the article: glycoconjugates of 99mTc(V) and the more recently developed [99mTc(I)(CO)3]+. Significant work in the last decade has featured the very attractive [99mTc(CO)3]+ core, and the ligand sets designed for this core are discussed in detail.

Graphical abstract: 99m-Technetium carbohydrate conjugates as potential agents in molecular imaging

Article information

Article type
Feature Article
Submitted
03 Jun 2008
Accepted
10 Jul 2008
First published
12 Sep 2008

Chem. Commun., 2008, 5077-5091

99m-Technetium carbohydrate conjugates as potential agents in molecular imaging

M. L. Bowen and C. Orvig, Chem. Commun., 2008, 5077 DOI: 10.1039/B809365B

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