Issue 41, 2008
From the journal:

Chemical Communications

Detoxification system for inorganic arsenic: transformation of As2O3 into TMAO by vitamin B12 derivatives and conversion of TMAO into arsenobetaine†

Koichiro Nakamura,*a   Yoshio Hisaeda,b   Ling Panb  and  Hiroshi Yamauchic  

* Corresponding authors

a R & D Department, Nippon Sheet Glass Co., Ltd., Chitose-cho 2, Yokkaichi, Mie, Japan
E-mail: KoichiroNakamura@mail.nsg.co.jp
Fax: +81-59-353-4707
Tel: +81-59-352-2493

b Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Moto-oka 744, Nishi-ku, Japan
E-mail: yhisatcm@mail.cstm.kyushu-u.ac.jp
Fax: +81-92-802-2827
Tel: +81-92-802-2826

c School of Allied Health Sciences, Kitasato University, Kitasato 1-15-1, Sagamihara, Kanagawa, Japan
E-mail: hyama@kitasato-u.ac.jp
Fax: +81-42-778-8113
Tel: +81-42-778-8113

Abstract

A new two-step synthetic pathway developed for the transformation of arsenic trioxide [iAs(III); As2O3] into arsenobetaine (AB; Me3As+CH2CO2−) involves treatment of iAs(III) with native B12 or biomimetic B12 in the presence of glutathione (GSH) to give TMAO with a high selectivity and a high conversion rate; subsequent treatment of TMAO with iodoacetic acid in the presence of GSH gives arsenobetaine.

Graphical abstract: Detoxification system for inorganic arsenic: transformation of As2O3 into TMAO by vitamin B12 derivatives and conversion of TMAO into arsenobetaine

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Article information

DOI
https://doi.org/10.1039/B808937J
Article type
Communication
Submitted
27 May 2008
Accepted
26 Aug 2008
First published
25 Sep 2008

Chem. Commun., 2008, 5122-5124

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Detoxification system for inorganic arsenic: transformation of As2O3 into TMAO by vitamin B12 derivatives and conversion of TMAO into arsenobetaine

K. Nakamura, Y. Hisaeda, L. Pan and H. Yamauchi, Chem. Commun., 2008, 5122 DOI: 10.1039/B808937J

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