Issue 39, 2008
From the journal:

Chemical Communications

Diaryl ether synthesis in supercritical carbon dioxide in batch and continuous flow modes†

Jin-Kyun Lee,ab   Matthew J. Fuchter,c   Rachel M. Williamson,d   Gary A. Leeke,e   Edward J. Bush,f   Ian F. McConvey,f   Simon Saubern,c   John H. Ryanc  and  Andrew B. Holmes*d  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Cambridge, UK

b Department of Materials Science and Engineering, Cornell University, Ithaca, USA

c CSIRO Molecular and Health Technologies, Bag 10, Clayton South, Australia

d School of Chemistry, Bio21 Institute, University of Melbourne, Australia
E-mail: aholmes@unimelb.edu.au
Fax: +61 3 8344 2384
Tel: +61 3 8344 2382

e Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, UK

f AstraZeneca Process Research and Development, Macclesfield, Cheshire, UK

Abstract

A high yielding, batch mode synthesis of diaryl ethers and sulfides by an SNAr fluoride-mediated process in scCO2 has been developed; the use of a polymer-supported imidazolium fluoride reagent in batch mode led to the development of a fixed-bed continuous flow process, with high conversions.

Graphical abstract: Diaryl ether synthesis in supercritical carbon dioxide in batch and continuous flow modes

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Article information

DOI
https://doi.org/10.1039/B808374F
Article type
Communication
Submitted
19 May 2008
Accepted
27 Jun 2008
First published
06 Aug 2008

Chem. Commun., 2008, 4780-4782

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Diaryl ether synthesis in supercritical carbon dioxide in batch and continuous flow modes

J. Lee, M. J. Fuchter, R. M. Williamson, G. A. Leeke, E. J. Bush, I. F. McConvey, S. Saubern, J. H. Ryan and A. B. Holmes, Chem. Commun., 2008, 4780 DOI: 10.1039/B808374F

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