Issue 31, 2008
From the journal:

Chemical Communications

G-quadruplex-based DNAzyme for facile colorimetric detection of thrombin

Tao Li,a   Erkang Wanga  and  Shaojun Dong*a  

* Corresponding authors

a State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China, and Graduate School of the Chinese Academy of Sciences, Beijing, China
E-mail: dongsj@ciac.jl.cn
Fax: (+86) 431-85689711
Tel: (+86) 431-85262101

Abstract

Thrombin-binding aptamer is found to bind hemin to form a catalytic complex whose activity is significantly promoted by the addition of thrombin, which enables the colorimetric detection of thrombin with high specificity and sensitivity in a facile way.

Graphical abstract: G-quadruplex-based DNAzyme for facile colorimetric detection of thrombin

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Article information

DOI
https://doi.org/10.1039/B805565C
Article type
Communication
Submitted
02 Apr 2008
Accepted
23 Apr 2008
First published
09 Jun 2008

Chem. Commun., 2008, 3654-3656

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G-quadruplex-based DNAzyme for facile colorimetric detection of thrombin

T. Li, E. Wang and S. Dong, Chem. Commun., 2008, 3654 DOI: 10.1039/B805565C

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