Issue 27, 2008
From the journal:

Chemical Communications

Substrate mediated reduction of copper-amyloid-β complex in Alzheimer’s disease†

Victor A. Streltsov*a  and  Joseph N. Varghesea  

* Corresponding authors

a CSIRO Molecular and Health Technologies and P-Health Flagship, Parkville, Australia
E-mail: victor.streltsov@csiro.au
Fax: +613 9662 7101
Tel: +613 9662 7311

Abstract

X-Ray absorption near-edge spectroscopy (XANES) has been used to probe the substrate mediated reduction of Cu2+ in Aβ-Cu2+ complexes by ascorbate and the neurotoxin 6-hydroxydopamine (6-OHDA), however dopamine and, in particular, cholesterol are incapable of reducing soluble monomeric Aβ-Cu2+ complexes.

Graphical abstract: Substrate mediated reduction of copper-amyloid-β complex in Alzheimer’s disease

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Article information

DOI
https://doi.org/10.1039/B803911A
Article type
Communication
Submitted
06 Mar 2008
Accepted
15 Apr 2008
First published
14 May 2008

Chem. Commun., 2008, 3169-3171

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Substrate mediated reduction of copper-amyloid-β complex in Alzheimer’s disease

V. A. Streltsov and J. N. Varghese, Chem. Commun., 2008, 3169 DOI: 10.1039/B803911A

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