Issue 32, 2008
From the journal:

Chemical Communications

Chemoenzymatic acylation of aminoglycoside antibiotics†

Nicholas M. Llewellyn*a  and  Jonathan B. Spencer‡a  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, United Kingdom
E-mail: nml30@cam.ac.uk
Fax: +44 (0)1223 336362
Tel: +44 (0)1223 336710

Abstract

The chemoenzymatic installation of the clinically valuable (S)-4-amino-2-hydroxybutyryl side chain onto a number of 2-deoxystreptamine-containing aminoglycosides is described using the purified Bacillus circulans biosynthetic enzymes BtrH and BtrG in combination with a synthetic acyl-SNAC surrogate substrate.

Graphical abstract: Chemoenzymatic acylation of aminoglycoside antibiotics

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Article information

DOI
https://doi.org/10.1039/B802248H
Article type
Communication
Submitted
08 Feb 2008
Accepted
15 May 2008
First published
20 Jun 2008

Chem. Commun., 2008, 3786-3788

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Chemoenzymatic acylation of aminoglycoside antibiotics

N. M. Llewellyn and J. B. Spencer, Chem. Commun., 2008, 3786 DOI: 10.1039/B802248H

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