Issue 14, 2008

N-Metalated imines by reaction of 1,1-diethoxybut-2-ene with aromatic nitriles, as useful intermediates for the synthesis of substituted pyrimidines and cyclopentenones

Abstract

A new approach to the synthesis of pyrimidines and cyclopentenones is described. The method exploits the reactivity of α,β-unsaturated acetals with aromatic nitriles in the presence of the Schlosser’s superbase LIC-KOR.

Graphical abstract: N-Metalated imines by reaction of 1,1-diethoxybut-2-ene with aromatic nitriles, as useful intermediates for the synthesis of substituted pyrimidines and cyclopentenones

Supplementary files

Article information

Article type
Communication
Submitted
20 Dec 2007
Accepted
29 Jan 2008
First published
07 Feb 2008

Chem. Commun., 2008, 1689-1691

N-Metalated imines by reaction of 1,1-diethoxybut-2-ene with aromatic nitriles, as useful intermediates for the synthesis of substituted pyrimidines and cyclopentenones

M. Blangetti, A. Deagostino, C. Prandi, C. Zavattaro and P. Venturello, Chem. Commun., 2008, 1689 DOI: 10.1039/B719462E

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