Total synthesis of spiruchostatin B, a potent histone deacetylase inhibitor, from a microorganism

Toshiya Takizawa; Kazuhiro Watanabe; Koichi Narita; Takamasa Oguchi; Hideki Abe; Tadashi Katoh

doi:10.1039/B718310K

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Total synthesis of spiruchostatin B, a potent histone deacetylase inhibitor, from a microorganism†

Toshiya Takizawa,^a Kazuhiro Watanabe,^a Koichi Narita,^a Takamasa Oguchi,^a Hideki Abe^a and Tadashi Katoh*^a

Author affiliations

* Corresponding authors

^a Laboratory of Synthetic Medicinal Chemistry, Department of Chemical Pharmaceutical Science, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Japan
E-mail: katoh@tohoku-pharm.ac.jp
Fax: +81-22-727-0135
Tel: +81-22-727-0135

Abstract

The first total synthesis of spiruchostatin B, a potent histone deacetylase inhibitor, was achieved in a convergent manner; the synthesis established stereochemistry at the C5″ position.

Download options Please wait...

Supplementary files

Experimental procedures and characterization data for all new compounds along with copies of ¹H and ¹³C NMR spectra PDF (2916K)

Article information

DOI: https://doi.org/10.1039/B718310K
Article type: Communication
Submitted: 27 Nov 2007
Accepted: 29 Jan 2008
First published: 05 Feb 2008

Download Citation

Chem. Commun., 2008, 1677-1679

Permissions

Request permissions

Total synthesis of spiruchostatin B, a potent histone deacetylase inhibitor, from a microorganism

T. Takizawa, K. Watanabe, K. Narita, T. Oguchi, H. Abe and T. Katoh, Chem. Commun., 2008, 1677 DOI: 10.1039/B718310K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications

Total synthesis of spiruchostatin B, a potent histone deacetylase inhibitor, from a microorganism†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Total synthesis of spiruchostatin B, a potent histone deacetylase inhibitor, from a microorganism

Social activity

Search articles by author

Spotlight

Advertisements