Issue 7, 2008

Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles

Abstract

The crystal structure of a DNA duplex with tricyclo-DNA (tc-DNA) residues explains the increased RNA affinity of tc-DNA relative to DNA and tc-DNA's superior resistance to nucleases.

Graphical abstract: Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles

Supplementary files

Article information

Article type
Communication
Submitted
24 Oct 2007
Accepted
29 Nov 2007
First published
21 Dec 2007

Chem. Commun., 2008, 883-885

Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles

P. S. Pallan, D. Ittig, A. Héroux, Z. Wawrzak, C. J. Leumann and M. Egli, Chem. Commun., 2008, 883 DOI: 10.1039/B716390H

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