Structural features of the Cu(ii) complex with the rat Aβ(1–28) fragment†
Abstract
The interaction between Cu(II) and the rat amyloid β (1–28) fragment in micellar solutions at pH 7.5 was investigated by CD and NMR spectroscopy; the proton–copper distances were used in restrained molecular dynamics simulations to obtain a structural model of the Cu(II) complex.