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Issue 9, 2008
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Immunotherapy: a way to improve the therapeutic outcome of photodynamic therapy?

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Abstract

Photodynamic therapy (PDT) is a treatment for cancer and non-cancerous lesions involving light and a sensitizing drug, a so-called photosensitizer. Photosensitizers for PDT usually accumulate in tumour tissues with some selectivity. Thus, malignant and abnormal cells can be destroyed by PDT which acts by producing singlet oxygen and possible other reactive oxygen species. However, the efficiency of PDT is often limited by shallow light penetration into tissue. In some cases one treatment modality cannot cure a patient because of treatment limitations and/or side effects. In recent years, many preclinical studies have indicated that the therapeutic outcome of PDT can be improved, doses and side effects lowered by combination with immunotherapy. Most experiments have been done with animals and cell lines. This review summarizes the current knowledge about different immunotherapeutic approaches which can be used to improve effectiveness and extend the applications of PDT in clinics.

Graphical abstract: Immunotherapy: a way to improve the therapeutic outcome of photodynamic therapy?

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Publication details

The article was received on 21 Apr 2008, accepted on 02 Jul 2008 and first published on 21 Jul 2008


Article type: Perspective
DOI: 10.1039/B806710D
Photochem. Photobiol. Sci., 2008,7, 1011-1017

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    Immunotherapy: a way to improve the therapeutic outcome of photodynamic therapy?

    M. Kwitniewski, A. Juzeniene, R. Glosnicka and J. Moan, Photochem. Photobiol. Sci., 2008, 7, 1011
    DOI: 10.1039/B806710D

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