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Issue 4, 2008
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High stereoselectivity in chelation-controlled intermolecular Heck reactions with aryl chlorides, vinyl chlorides and vinyl triflates

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Abstract

Highly stereoselective chelation-controlled Pd(0)-catalyzed β-arylations and β-vinylations of a five-membered chiral, pyrrolidine-based vinyl ether were achieved using aryl- and vinyl chlorides as substrates, yielding quaternary 2-aryl/vinyl-2-methyl cyclopentanones in 89–96% ee under neutral reaction conditions.

Graphical abstract: High stereoselectivity in chelation-controlled intermolecular Heck reactions with aryl chlorides, vinyl chlorides and vinyl triflates

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Article information


Submitted
11 Dec 2007
Accepted
14 Dec 2007
First published
08 Jan 2008

Org. Biomol. Chem., 2008,6, 674-676
Article type
Communication

High stereoselectivity in chelation-controlled intermolecular Heck reactions with aryl chlorides, vinyl chlorides and vinyl triflates

G. K. Datta and M. Larhed, Org. Biomol. Chem., 2008, 6, 674
DOI: 10.1039/B719131F

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