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Issue 7, 2008
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Bifunctional ligands based on the DOTA-monoamide cage

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Abstract

Efficient routes to DOTA-monoamide ligands bearing amino, hydroxyl, aldehyde and maleimido groups are described. These functional groups, which can be spaced at will from the coordination cage, will readily react with suitable groups of targeting moieties. Bioconjugates obtained in this way can be used for diagnostic imaging and therapeutic applications.

Graphical abstract: Bifunctional ligands based on the DOTA-monoamide cage

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Publication details

The article was received on 15 Oct 2007, accepted on 28 Jan 2008 and first published on 22 Feb 2008


Article type: Paper
DOI: 10.1039/B715844K
Org. Biomol. Chem., 2008,6, 1176-1184

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    Bifunctional ligands based on the DOTA-monoamide cage

    A. Barge, L. Tei, D. Upadhyaya, F. Fedeli, L. Beltrami, R. Stefanìa, S. Aime and G. Cravotto, Org. Biomol. Chem., 2008, 6, 1176
    DOI: 10.1039/B715844K

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