Issue 10, 2008
From the journal:

Organic & Biomolecular Chemistry

Synthesis of imidazolidin-2-one-4-carboxylate and of (tetrahydro)pyrimidin-2-one-5-carboxylatevia an efficient modification of the Hofmann rearrangement†

Gaetano Angelici,a   Simone Contaldi,a   Sarah Lynn Greenb  and  Claudia Tomasini*a  

* Corresponding authors

a Dipartimento di Chimica “G. Ciamician” - Alma Mater Studiorum, Università di Bologna, Via Selmi 2, 40126 Bologna, Italy
E-mail: claudia.tomasini@unibo.it
Fax: +39-0512099456
Tel: +39-0512099596

b School of Chemistry, Trinity College Dublin, Dublin 2, Ireland

Abstract

A mild and efficient methodology for the rearrangement of protected asparagine and protected glutamine is reported; good results are obtained with a wide selection of protecting groups.

Graphical abstract: Synthesis of imidazolidin-2-one-4-carboxylate and of (tetrahydro)pyrimidin-2-one-5-carboxylatevia an efficient modification of the Hofmann rearrangement

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Article information

DOI
https://doi.org/10.1039/B801909F
Article type
Paper
Submitted
01 Feb 2008
Accepted
05 Mar 2008
First published
07 Apr 2008

Org. Biomol. Chem., 2008,6, 1849-1852

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Synthesis of imidazolidin-2-one-4-carboxylate and of (tetrahydro)pyrimidin-2-one-5-carboxylatevia an efficient modification of the Hofmann rearrangement

G. Angelici, S. Contaldi, S. Lynn Green and C. Tomasini, Org. Biomol. Chem., 2008, 6, 1849 DOI: 10.1039/B801909F

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