Jump to main content
Jump to site search

Issue 5, 2008
Previous Article Next Article

Activity and selectivity of W110A secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus in organic solvents and ionic liquids: mono- and biphasic media

Author affiliations

Abstract

The asymmetric reduction of hydrophobic phenyl-ring-containing ketones and the enantiospecific kinetic resolution of the corresponding racemic alcohols catalyzed by Thermoanaerobacter ethanolicus W110A secondary alcohol dehydrogenase were performed in mono- and biphasic systems containing either organic solvents or ionic liquids. Both yield and enantioselectivity for these transformations can be controlled by changing the reaction medium. The enzyme showed high tolerance to both water-miscible and -immiscible solvents, which allows biotransformations to be conducted at high substrate concentrations.

Graphical abstract: Activity and selectivity of W110A secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus in organic solvents and ionic liquids: mono- and biphasic media

Back to tab navigation

Publication details

The article was received on 06 Nov 2007, accepted on 17 Dec 2007 and first published on 18 Jan 2008


Article type: Paper
DOI: 10.1039/B717120J
Org. Biomol. Chem., 2008,6, 887-892

  •   Request permissions

    Activity and selectivity of W110A secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus in organic solvents and ionic liquids: mono- and biphasic media

    M. M. Musa, K. I. Ziegelmann-Fjeld, C. Vieille and R. S. Phillips, Org. Biomol. Chem., 2008, 6, 887
    DOI: 10.1039/B717120J

Search articles by author

Spotlight

Advertisements