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Issue 4, 2008
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A hitchhiker's guide to G-quadruplex ligands

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Over the past decade, nucleic acid chemists have seen the spectacular emergence of molecules designed to interact efficiently and selectively with a peculiar DNA structure named G-quadruplex. Initially derived from classical DNA intercalators, these G-quadruplex ligands progressively became the focal point of new excitement since they appear to inhibit selectively the growth of cancer cells thereby opening interesting perspectives towards the development of novel anti-cancer drugs. The present article aims to help researchers enter this exciting research field, and to highlight recent advances in the design of G-quadruplex ligands.

Graphical abstract: A hitchhiker's guide to G-quadruplex ligands

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The article was received on 25 Sep 2007, accepted on 23 Oct 2007 and first published on 14 Nov 2007

Article type: Emerging Area
DOI: 10.1039/B714772B
Org. Biomol. Chem., 2008,6, 627-636

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    A hitchhiker's guide to G-quadruplex ligands

    D. Monchaud and M. Teulade-Fichou, Org. Biomol. Chem., 2008, 6, 627
    DOI: 10.1039/B714772B

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