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Issue 4, 2008
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Knipholone and related 4-phenylanthraquinones: structurally, pharmacologically, and biosynthetically remarkable natural products

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Abstract

Covering: up to May 2008

This review gives the first comprehensive overview of the rapidly emerging young class of 4-phenylanthraquinones isolated from the three genera Bulbine, Bulbinella, and Kniphofia, all from the plant family Aphodelaceae: their occurrence, structural elucidation (with particular emphasis on the phenomenon of axial chirality), partial and total synthesis, their pharmacological (i.a., antimalarial and antitumoral) activities, and their biosynthetic origin (from acetate units). Particular emphasis is given to the stereostructure of knipholone, the most abundant of these naturally occurring phenylanthraquinones. The most recent highlight is the discovery of the first dimeric representatives, named joziknipholones, involving interesting phenomena of—partially or fully restricted—rotation at the sp2–sp2 and sp2–sp3 axes.

Graphical abstract: Knipholone and related 4-phenylanthraquinones: structurally, pharmacologically, and biosynthetically remarkable natural products

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Publication details

The article was received on 04 Mar 2008 and first published on 23 Jun 2008


Article type: Review Article
DOI: 10.1039/B803784C
Nat. Prod. Rep., 2008,25, 696-718

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    Knipholone and related 4-phenylanthraquinones: structurally, pharmacologically, and biosynthetically remarkable natural products

    G. Bringmann, J. Mutanyatta-Comar, M. Knauer and B. M. Abegaz, Nat. Prod. Rep., 2008, 25, 696
    DOI: 10.1039/B803784C

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