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Issue 7, 2008
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Amyloid fibrils: modulation of formation and structure by copper(ii)

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Abstract

The role of CuII-complexation of amyloidogenic peptides on the formation and structure of aggregates were analyzed in order to obtain a general insight into modulation of peptide aggregation by metal ions. The results mimicked various facets of biological relevant peptides/protein-aggregation. Important mechanistic features are the ability of CuII to associate the peptides by bridging coordination, the structural changes induced by CuII binding and their effect on peptide–peptide interactions.

Graphical abstract: Amyloid fibrils: modulation of formation and structure by copper(ii)

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Article information


Submitted
19 Dec 2007
Accepted
23 Jan 2008
First published
19 Feb 2008

New J. Chem., 2008,32, 1189-1194
Article type
Paper

Amyloid fibrils: modulation of formation and structure by copper(II)

V. Pradines, A. J. Stroia and P. Faller, New J. Chem., 2008, 32, 1189
DOI: 10.1039/B719556G

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