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Issue 4, 2008
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Use of samarium diiodide in the field of asymmetric synthesis

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Abstract

Samarium diiodide may be a useful reagent in a step of an asymmetric synthesis process. It can release a blocking group in mild conditions, as described in several examples. SmI2 has been used as electron donor in many C–C bond formations in presence of a chiral auxiliary. It can also generate samarium enolates which were subjected to asymmetric protonation. The examples selected in this review of SmI2 methodology concern only the cases where the chiral auxiliary is not retained in the final product.

Graphical abstract: Use of samarium diiodide in the field of asymmetric synthesis

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Publication details

The article was received on 27 Nov 2007, accepted on 31 Jan 2008 and first published on 26 Feb 2008


Article type: Perspective
DOI: 10.1039/B718330P
New J. Chem., 2008,32, 607-637

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    Use of samarium diiodide in the field of asymmetric synthesis

    K. Gopalaiah and H. B. Kagan, New J. Chem., 2008, 32, 607
    DOI: 10.1039/B718330P

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