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Issue 11, 2008
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Single molecule studies of homologous recombination

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Abstract

Single molecule methods offer an unprecedented opportunity to examine complex macromolecular reactions that are obfuscated by ensemble averaging. The application of single molecule techniques to study DNA processing enzymes has revealed new mechanistic details that are unobtainable from bulk biochemical studies. Homologous DNA recombination is a multi-step pathway that is facilitated by numerous enzymes that must precisely and rapidly manipulate diverse DNA substrates to repair potentially lethal breaks in the DNA duplex. In this review, we present an overview of single molecule assays that have been developed to study key aspects of homologous recombination and discuss the unique information gleaned from these experiments.

Graphical abstract: Single molecule studies of homologous recombination

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Article information


Submitted
08 Jul 2008
Accepted
28 Aug 2008
First published
29 Sep 2008

Mol. BioSyst., 2008,4, 1094-1104
Article type
Review Article

Single molecule studies of homologous recombination

I. J. Finkelstein and E. C. Greene, Mol. BioSyst., 2008, 4, 1094
DOI: 10.1039/B811681B

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