Issue 6, 2008
From the journal:

Lab on a Chip

Nano-biopower supplies for biomolecular motors: the use of metabolic pathway-based fuel generating systems in microfluidic devices†‡

Joshua R. Wasylycia,ab   Svetlana Sapelnikova,ab   Hyuk Jeong,c   Jelena Dragoljic,a   Sandra L. Marcusa  and  D. Jed Harrison*ab  

* Corresponding authors

a Deptartment of Chemistry, University of Alberta, Edmonton, AB, Canada

b National Institute for Nanotechnology, National Research Council of Canada, Edmonton, Alberta, Canada

c Deptartment of Chemistry, Sookmyung Women's University, Seoul, Korea

Abstract

We report fuel generation systems for molecular motors based on pyruvate kinase, or for the first time, mitochondria, implemented within microfluidic devices. Intact organelles acted as bio-nanopower supplies for molecular motors, using isolated mitochondria to convert chemical energy from succinate to ATP, harnessing nature's enzymatic transformation cascades directly. Motors were activated essentially equally by ATP produced by pyruvate kinase, mitochondria, or direct addition of ATP.

Graphical abstract: Nano-biopower supplies for biomolecular motors: the use of metabolic pathway-based fuel generating systems in microfluidic devices

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Article information

DOI
https://doi.org/10.1039/B801033A
Article type
Technical Note
Submitted
21 Jan 2008
Accepted
12 Mar 2008
First published
11 Apr 2008

Lab Chip, 2008,8, 979-982

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Nano-biopower supplies for biomolecular motors: the use of metabolic pathway-based fuel generating systems in microfluidic devices

J. R. Wasylycia, S. Sapelnikova, H. Jeong, J. Dragoljic, S. L. Marcus and D. J. Harrison, Lab Chip, 2008, 8, 979 DOI: 10.1039/B801033A

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