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Issue 12, 2008
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Development of functional lab-on-a-chip on polymer for point-of-care testing of metabolic parameters

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Abstract

This paper presents the development of an easy-to-handle and disposable clinical diagnostic lab-on-a-chip using fully integrated plastic microfluidic components, which has the sampling/identifying capability to make fast and reliable measurements of metabolic parameters from human whole blood. A smart and functional lab-on-a-chip cartridge, which incorporates a full on-chip auto-calibration function for in the field applications, has been developed, and then fully characterized using a portable analyzer (3 ¼″ × 5″ × 1″) with multi-analyte detection capability. In addition, several new approaches in realizing smart and functional lab-on-a-chips on polymer have been adopted, which include the pinch valve for automatic fluidic sealing, a by-pass channel as the sampling indicator, and a robust connector design for long analyzer lifetimes. Metabolic parameters such as glucose, lactate, and partial oxygen from human whole blood have been successfully measured using the functional polymer lab-on-a-chips and the portable analyzer developed in this work.

Graphical abstract: Development of functional lab-on-a-chip on polymer for point-of-care testing of metabolic parameters

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Article information


Submitted
02 Jul 2008
Accepted
17 Sep 2008
First published
23 Oct 2008

Lab Chip, 2008,8, 2113-2120
Article type
Paper

Development of functional lab-on-a-chip on polymer for point-of-care testing of metabolic parameters

J. Do, S. Lee, J. Han, J. Kai, C. Hong, C. Gao, J. H. Nevin, G. Beaucage and C. H. Ahn, Lab Chip, 2008, 8, 2113
DOI: 10.1039/B811169C

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