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Issue 6, 2008
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Managing evaporation for more robust microscale assays

Part 1. Volume loss in high throughput assays

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Abstract

Evaporation is a well known issue when handling small liquid volumes. Here we present a review of microscale assays prone to evaporation and methods to make them more robust. Applications for these assays span from combinatorial chemistry to cell-biology where the stability of concentrations and osmolarity can be critical. A dimensionless evaporation number Ev is presented and used to characterize volume loss in short term and long term microscale assays. Ev can be used both as a design tool and as an analysis parameter. The advantageous use of evaporation in some applications is also discussed.

Graphical abstract: Managing evaporation for more robust microscale assays Part 1. Volume loss in high throughput assays

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Article information


Submitted
12 Nov 2007
Accepted
11 Mar 2008
First published
08 Apr 2008

Lab Chip, 2008,8, 852-859
Article type
Tutorial Review

Managing evaporation for more robust microscale assays

E. Berthier, J. Warrick, H. Yu and D. J. Beebe, Lab Chip, 2008, 8, 852
DOI: 10.1039/B717422E

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