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Issue 5, 2008
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Automated cell culture in high density tubeless microfluidic device arrays

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Abstract

Microfluidics is poised to have an impact on life sciences research. However, current microfluidic methods are not compatible with existing laboratory liquid dispensing and detection infrastructure. This incompatibility is a barrier to adoption of microfluidic systems and calls for improved approaches that will enhance performance and promote acceptance of microfluidic systems in the life sciences. Ease of use, standardized interfaces and automation remain critical challenges. We present a platform based on surface tension effects, where the difference in pressure inside drops of unequal volume drives flow in passive structures. We show integration with existing laboratory infrastructure, microfluidic operations such as pumping, routing and compartmentalization without discrete micro-components as well as cell patterning in both monolayer and three-dimensional cell culture.

Graphical abstract: Automated cell culture in high density tubeless microfluidic device arrays

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Article information


Submitted
08 Oct 2007
Accepted
01 Feb 2008
First published
20 Mar 2008

Lab Chip, 2008,8, 717-724
Article type
Paper

Automated cell culture in high density tubeless microfluidic device arrays

I. Meyvantsson, J. W. Warrick, S. Hayes, A. Skoien and D. J. Beebe, Lab Chip, 2008, 8, 717
DOI: 10.1039/B715375A

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