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Issue 42, 2008
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Stability and size dependence of protein microspheres prepared by ultrasonication

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Abstract

Protein microspheres have been prepared by sonicating oil in an aqueous protein solution. Such prepared microspheres can be used in magnetic resonance imaging (MRI), micro-encapsulation, and drug delivery systems. When they are used in the blood circulation, their size and stability become most important. In this paper, the factors affecting the size and size distribution of these microspheres are discussed and a way to control the size of the microspheres is put forward. Small microspheres with size less than 1 µm were selected by gravitational sedimentation. The selected microspheres have a narrow size distribution and can be used in the blood circulation safely. The loading of dye into these microspheres was easily achieved by dissolution of drugs in the oil phase before sonication. The protein microspheres showed excellent protection for the loaded dye, which can be stably carried for several weeks.

Graphical abstract: Stability and size dependence of protein microspheres prepared by ultrasonication

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Publication details

The article was received on 06 May 2008, accepted on 15 Aug 2008 and first published on 23 Sep 2008


Article type: Paper
DOI: 10.1039/B807615D
J. Mater. Chem., 2008,18, 5162-5166

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    Stability and size dependence of protein microspheres prepared by ultrasonication

    Y. Han, D. Radziuk, D. Shchukin and H. Moehwald, J. Mater. Chem., 2008, 18, 5162
    DOI: 10.1039/B807615D

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